Philippa marrack biography sample

The couple met in as postdoctoral fellows at the University of California in San Diego and launched a joint lab with their first jobs at the University of Rochester. Kappler is a whiz at protein chemistry and new technologies. Marrack matches that with a deep knowledge of the field and an attention to detail. Their complementary approach has made their lab a powerhouse for the past 30 years.

From the beginning, the pair set ground rules to avoid any domestic strain: they would publish all papers together and the primary driver of a study would take lead authorship. A s hypothesis had proposed that immature T cells that inappropriately recognize 'self' would be deleted in the thymus before maturing into circulating immune cells.

While screening antibodies for the various types of T cell receptors, the lab discovered that a whole subpopulation of T cells is missing in certain mice. In the United States she met her lifelong partner and husband, John W. They have completed much research and accomplished many advancements in the fields of immunology, biochemistry, and molecular biology.

Marrack and Kappler have two children together. Outside of science, Philippa Marrack enjoys playing the piano, as well as running along the Platte River with her Labradors.

Philippa marrack biography sample

Education Marrack completed both undergraduate and Ph. During her Ph. Alan Munro became her thesis advisor; she became the graduate student that worked with him due to his interest in working with a relative of John Marrack. Her numerous citations and journal articles places her as the third most influential researcher in the nation and distinguishes her as top female researcher.

Resulting from this research, in Marrack discovered how the immune system is capable of molecular discrimination, as the human body can get rid of T cells that target the body's own tissues, destroying them in the thymus before they have a chance to cause problems, yet the body retains the cells that combat invaders. She learned that destructive cells that fail to be destroyed can cause autoimmune diseases like AIDS , diabetes , Multiple sclerosis , and lupus.

This foundational work on immunological tolerance by Marrack and Kappler led to their later discovery in of superantigens : powerful toxins that stimulate a large amounts of T-cell proliferation and can cause devastating immune response and violent symptoms such as those seen in toxic shock syndrome or food poisoning. Influenza nucleoprotein delivered with aluminium salts protects mice from an influenza A virus that expresses an altered nucleoprotein sequence.

PLoS One. Ikaros promotes secondary rearrangement of T cell receptor alpha genes. McKee1, Matthew A. Burchill2,3, Michael W. Recognition of self and altered self by T cells in autoimmunity and allergy. A closer look at TCR germline recognition. Immunity , Age-associated B cells: are they the key to understanding why autoimmune diseases are more prevalent in women?

Expert Rev. Nature Immunol.